Directors of the institute
| 1905 – 1941 |
| | Prof. Dr. med. Dr. h.c. Heinrich Zangger |
| 1941 – 1968 |
| | Prof. Dr. med. Fritz Schwarz |
| 1969 – 1988 |
| | Prof. Dr. med. Hanspeter Hartmann |
| 1989 – 2011 |
| | Prof. Dr. med. Dr. h.c. Walter Bär |
| since 2011 | | | Prof. Dr. med. Michael Thali |